GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs610041 | chr11:71797968 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.81 | 0.000158 | Severe influenza A (H1N1) infection |
| THCA | cis | rs8180209 | 1 | rs61032876 | chr4:90641403 | MMRN1 | chr4:90816003-90875778:+ | 0.32 | 4.07 | 5.5E-5 | Parkinson's disease |
| THCA | cis | rs4237643 | 1 | rs61037750 | chr11:43681372 | HSD17B12 | chr11:43702143-43878160:+ | -0.69 | -14.35 | 4.51E-39 | Forced vital capacity |
| THCA | cis | rs12435908 | 1 | rs61038704 | chr14:66172300 | LOC645431 | chr14:65877313-65879335:- | -0.48 | -6.02 | 3.52E-9 | Ischemic stroke |
| THCA | cis | rs61041336 | 1 | rs61041336 | chr16:58733162 | GOT2 | chr16:58741035-58768246:- | 0.22 | 4.85 | 1.71E-6 | Neuritic plaque |
| THCA | cis | rs73201462 | 1 | rs61044849 | chr3:128065466 | EEFSEC | chr3:127872313-128127488:+ | -0.22 | -3.79 | 0.000173 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs1552244 | 1 | rs61052895 | chr3:10147516 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.52 | 7.91E-6 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs61052895 | chr3:10147516 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.52 | 7.86E-6 | Alzheimer's disease |
| THCA | cis | rs932541 | 1 | rs6105609 | chr20:16457330 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6105610 | chr20:16457333 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.74 | 0.000204 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6105612 | chr20:16458404 | KIF16B | chr20:16252749-16554078:- | -0.17 | -3.85 | 0.000136 | Intelligence |
| THCA | cis | rs3820928 | 1 | rs61067328 | chr2:227761256 | COL4A4 | chr2:227867435-228029275:- | 0.16 | 3.91 | 0.000105 | Pulmonary function |
| THCA | cis | rs7267979 | 1 | rs6107033 | chr20:25363591 | ENTPD6 | chr20:25176339-25207360:+ | 0.3 | 6.96 | 1.11E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6107033 | chr20:25363591 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.42 | 0.000686 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6107033 | chr20:25363591 | FAM182B | chr20:25744102-25848786:- | -0.25 | -5.37 | 1.26E-7 | Liver enzyme levels (alkaline phosphatase) |